Histocompatibility system (KIR)
For a correct immunological relationship between the mother and the embryo
What is the histocompatibility system (KIR)?
There are a number of immune mechanisms that protect our body against external aggressions, allowing an embryo to be accepted and develop normally.
In some cases, the relationship between the mother’s immune cells (uNK cells) and those of the embryo is inadequate. These cells have receptors (KIR) on their surface, which interact with the HLA-C antigens of the embryo. We now know that there are certain less compatible combinations between KIR and HLA-C, which can lead to implantation failure, miscarriage or pre-eclampsia.
To reduce this risk, a genetic analysis is carried out through blood samples from the mother and the father. In the case of gamete donation treatments, we ensure that the egg and/or sperm donors are immunologically compatible.
When is it used?
In cases with relevant past medical history
Unexplained implantation failures in previous treatments, repeated miscarriages or a history of previous pre-eclampsia.
In which treatments is it applied?
What happens if there is an incompatibility?
In that case, we can prescribe immunomodulatory medication for the mother. In cases where donation is necessary, it allows us to choose compatible donors and for the embryo to be immunologically compatible with the mother.
Any questions?
We are here to answer any questions you may have about this or other techniques and treatments. We will get back to you as soon as possible.
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