Endometrial immunology test

Analysis of the immune system prior to pregnancy

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What are endometrial immunology tests?

These tests allow us to identify imbalances in the immune system of the endometrium that may affect the outcome of the treatment. Because success in reproduction depends, among other aspects, on the woman’s immune system tolerating the implantation of the embryo and its subsequent development, without any adverse molecular reaction.

When is it used?


En casos con antecedentes adversos

Unexplained infertility, recurrent miscarriages, repeated implantation failures, or autoimmune-related disorders.

Benefits of carrying out endometrial immunology tests

Identification of immune problems that may affect pregnancy.

Personalisation of the treatment, increasing its chances of success.

Improvement of embryo implantation rates

Prevention of recurrent miscarriages.

How is an endometrial immunology test done?

The procedure is simple. A sample of the patient’s endometrium is taken by biopsy and analysed by flow cytometry to assess the number, percentage and distribution of immune cells.

What information do the results provide?

The results of the analysis will allow us to know if the tissue is immunologically prepared (if it is inflammatory, normal or non-functional) for the correct implantation and development of the embryo. If any incompatibility is found, we will be able to indicate personalised immunomodulatory treatments for each case.

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FAQs about immunology tests


What is an endometrial immunology test?
This is a medical test to assess the immune response of the endometrium (the lining of the uterus). We can identify possible immune problems that affect embryo implantation and the success of the pregnancy.
When is an endometrial immunology test recommended?
Always under medical advice, it can be recommended in cases of unexplained infertility, repeated IVF treatment failures and recurrent miscarriages. It may also be indicated if there are suspected immunological disorders affecting the endometrium.
How is an endometrial immunology test performed?
By obtaining a sample of the endometrium through an endometrial biopsy. The sample is then analysed in a laboratory to evaluate various immunological markers and immune system cells present in the tissue.
What types of immunological markers are analysed in this test?
Several markers are analysed, including NK (natural killer) cells, T lymphocytes, and the expression of molecules such as cytokines. These markers help determine if there is an abnormal immune response in the endometrium.
What happens if an endometrial immune problem is detected?
We may prescribe treatment, which may vary depending on the type and severity of the problem detected. Some options include the use of corticosteroids to reduce inflammation, intravenous immunoglobulins (IVIg) to modulate the immune response, and treatments with anticoagulants or specific biological therapies.